C–S Bond Activation

Laboratory Equivalents of C-h Bond Activation

INTRODUCTION Medicinal drugs act in the body by a variety of biochemical mechanisms. Depending on the types of functional groups found on the drug, the drug can react in one of the many compartments it passes through during metabolism. Some drugs are able to avoid side reactions, but there are some that are broken down or take effect in an undesired place. Prodrugs, inactive forms of drugs, are...

Transition-metal catalysed C-N bond activation.

Transition-metal catalysed C-N bond activation has attracted much attention and become one of the most promising bond disconnection and formation strategies that encompass a broad spectrum of applications in many reactions. In this tutorial review, efficient strategies for catalytic cleavage of C(sp)-N, C(sp(2))-N and C(sp(3))-N bonds and their applications in new C-C and C-N bond formation rea...

Transition metal-catalyzed carbon-carbon bond activation.

This tutorial review deals with recent developments in the activation of C-C bonds in organic molecules that have been catalyzed by transition metal complexes. Many chemists have devised a variety of strategies for C-C bond activation and significant progress has been made in this field over the past few decades. However, there remain only a few examples of the catalytic activation of C-C bonds...

A versatile ruthenium catalyst for C-C bond formation by C-H bond activation.

Catalytic Carbon–Chlorine Bond Activation by Selenium‐Based Chalcogen Bond Donors

Chalcogen bonding is a noncovalent interaction based on electrophilic chalcogen substituents, which shares many similarities with the more well-known hydrogen and halogen bonding. Herein, the first application of selenium-based chalcogen bond donors in organocatalysis is described. Cationic bifunctionalized organoselenium compounds activate the carbon-chlorine bond of 1-chloroisochroman in a be...